Gene and protein expression profiles of JAK-STAT signalling pathway in the developing brain of the Ts1Cje down syndrome mouse model

• Main Authors: Lee, Han Chung, Md Yusof, Hadri Hadi, Leong, Melody Pui Yee, Zainal Abidin, Shahidee, Seth, Eryse Amira, Hewitt, Chelsee A., Vidyadaran, Sharmili, Nordin, Norshariza, Scott, Hamish S., Cheah, Pike See, Ling, King Hwa
• Format: Article
• Published: Taylor & Francis 2019
• Online Access: http://psasir.upm.edu.my/id/eprint/79976/; https://www.tandfonline.com/doi/abs/10.1080/00207454.2019.1580280

Aims: The JAK-STAT signalling pathway is one of the key regulators of pro-gliogenesis process during brain development. Down syndrome (DS) individuals, as well as DS mouse models, exhibit an increased number of astrocytes, suggesting an imbalance of neurogenic-to-gliogenic shift attributed to dysreg...