Transcriptional profiling of the postnatal brain of the Ts1Cje mouse model of Down syndrome

• Main Authors: Tan, Kai Leng, Ling, King Hwa, Hewitt, Chelsee A., Cheah , Pike See, Simpson, Ken M., Gordon, Lavinia, Pritchard, Melanie A., Smyth, Gordon K., Thomas, Tim, Scott, Hamish S.
• Format: Article
• Language: English
• Published: Elsevier 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/35883/1/Transcriptional%20profiling%20of%20the%20postnatal%20brain%20of%20the%20Ts1Cje%20mouse.pdf; http://psasir.upm.edu.my/id/eprint/35883/; http://www.sciencedirect.com/science/article/pii/S2213596014000841

The Ts1Cje mouse model of Down syndrome (DS) has partial trisomy of mouse chromosome 16 (MMU16), which is syntenic to human chromosome 21 (HSA21). It develops various neuropathological features demonstrated by DS patients such as reduced cerebellar volume [1] and altered hippocampus-dependent learni...