The role of JAK-STAT signalling in the developing brain of Ts1Cje mouse model for Down syndrome

• Main Authors: Lee, Han Chung, Nordin, Norshariza, Vidyadaran, Sharmili, Cheah, Pike See, Ling, King Hwa
• Format: Conference or Workshop Item
• Language: English
• Published: 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/75599/1/The%20role%20of%20JAK-STAT%20signalling%20in%20the%20developing%20brain%20of%20Ts1Cje%20mouse%20model%20for%20Down%20syndrome.pdf; http://psasir.upm.edu.my/id/eprint/75599/

Introduction: The JAK-STAT signalling pathway is essential for proper regulation of the gliogenesis process during brain development. Both Down syndrome (DS) individuals and DS mouse model showed reduced number of neuron but increase number of astrocyte in the brain; suggesting that dysregulation of...