Expression profiling of notch signalling pathway and gamma-secretase activity in the brain of Ts1Cje mouse model of down syndrome

• Main Authors: Md Yusof, Hadri Hadi, Lee, Han Chung, Mohamed Seth, Eryse Amira, Wu, Xiangzhong, Hewitt, Chelsee A., Scott, Hamish S., Cheah, Pike See, Li, Yue Ming, Chau, De Ming, Ling, King Hwa
• Format: Article
• Published: Springer 2019
• Online Access: http://psasir.upm.edu.my/id/eprint/79827/; https://link.springer.com/article/10.1007/s12031-019-01275-2

Notch signalling pathway is involved in the proliferation of neural progenitor cells (NPCs), to inhibit neuronal cell commitment and to promote glial cell fate. Notch protein is cleaved by gamma-secretase, a multisubunit transmembrane protein complex that releases the Notch intracellular domain (NIC...