Curcumin, piperine, and capsaicin: a comparative study of spice-mediated inhibition of human cytochrome P450 isozyme activities

Inhibition of cytochrome P450 (P450) enzymes (CYP) has been shown to lower the metabolism of drugs that are P450 substrates and to consequently alter their pharmacokinetic profiles. Curcumin (CUR), piperine (PIP), and capsaicin (CAP) are spice components (SC) that inhibit the activities of a range o...

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Bibliographic Details
Main Authors: Suhaili, Shamsi, Huong, Tran, Seok, Renee Jin Tan, Zee, Jian Tan, Lee, Yong Lim
Format: Article
Language:English
Published: American Society for Pharmacology and Experimental Therapeutics (ASPET) 2017
Online Access:http://psasir.upm.edu.my/id/eprint/61267/1/Curcumin%2C%20piperine%2C%20and%20capsaicin%20a%20comparative%20study%20of%20spice-mediated%20inhibition%20of%20human%20cytochrome%20P450%20isozyme%20activities.pdf
http://psasir.upm.edu.my/id/eprint/61267/
http://dmd.aspetjournals.org/content/dmd/45/1/49.full.pdf
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