Efficient double Suzuki cross-coupling reactions of 2,5-dibromo-3-hexylthiophene: anti-tumor, haemolytic, anti-thrombolytic and biofilm inhibition studies

• Main Authors: Ikram, Hafiz Mansoor, Rasool, Nasir, Zubair, Muhammad, Khan, Khalid Mohammed, Chotana, Ghayoor Abbas, Akhtar, Muhammad Nadeem, Abu, Nadiah, Alitheen, Noorjahan Banu, Elgorban, Abdallah Mohamed, Rana, Usman Ali
• Format: Article
• Language: English
• Published: M D P I AG 2016
• Online Access: http://psasir.upm.edu.my/id/eprint/54128/1/Efficient%20double%20Suzuki.pdf; http://psasir.upm.edu.my/id/eprint/54128/; http://www.mdpi.com/1420-3049/21/8/977

The present study describes several novel 2,5-biaryl-3-hexylthiophene derivatives (3a-i) synthesized via a Pd(0)-catalyzed Suzuki cross-coupling reaction in moderate to good yields. The novel compounds were also analyzed for their anti-thrombolytic, haemolytic, and biofilm inhibition activities. In...