Selective C-arylation of 2,5-dibromo-3-hexylthiophene via Suzuki cross coupling reaction and their pharmacological aspects

• Main Authors: Ikram, Hafiz Mansoor, Rasool, Nasir, Ahmad, Gulraiz, Chotana, Ghayoor Abbas, Musharraf, Syed Ghulam, Zubair, Muhammad, Ali Rana, Usman, Zia-Ul-Haq, Muhammad, Jaafar, Hawa Z. E.
• Format: Article
• Language: English
• Published: MDPI 2015
• Online Access: http://psasir.upm.edu.my/id/eprint/46253/1/Selective%20C-arylation%20of%202%2C5-dibromo-3-hexylthiophene%20via%20Suzuki%20cross%20coupling%20reaction%20and%20their%20pharmacological%20aspects.pdf; http://psasir.upm.edu.my/id/eprint/46253/; https://www.mdpi.com/1420-3049/20/3/5202

The present study reports the synthesis of various new derivatives based on 5-aryl-2-bromo-3-hexylthiophene with moderate-to-good yields via a palladium-catalyzed Suzuki cross-coupling reaction. This coupling method involved the reaction of 2,5-dibromo-3-hexylthiophene with several arylboronic acids...