Palladium(0) catalyzed Suzuki cross-coupling reaction of 2,5-dibromo-3-methylthiophene: selectivity, characterization, DFT studies and their biological evaluations

• Main Authors: Rizwan, Komal, Zubair, Muhammad, Rasool, Nasir, Mahmood, Tariq, Ayub, Khurshid, Noorjahan Banu, Alitheen, Muhammad Nazirul Mubin, Aziz, Akhtar, Muhammad Nadeem, Nasim, Faiz-ul-Hassan, Bukhary, Snober Mona, Ahmad, Viqar Uddin, Rani, Mubeen
• Format: Article
• Language: English
• Published: Springer Open 2018
• Subjects: QD Chemistry
• Online Access: http://umpir.ump.edu.my/id/eprint/22383/1/Palladium%280%29%20catalyzed%20Suzuki%20cross.pdf; http://umpir.ump.edu.my/id/eprint/22383/; https://doi.org/10.1186/s13065-018-0404-7

Thiophene derivatives have shown versatile pharmacological activities. The Suzuki reaction proved a convenient method for C–C bond formations in organic molecules. In the present research work novel derivatives of 2,5-dibromo-3-methylthiophene (3a–k and 3l–p) has been synthesized, via Suzuki couplin...