Detection of active site conformation changes of gamma-secretase, a key enzyme associated with Alzheimer disease, with small molecules
Gamma-secretase is a membrane-bound aspartyl-protease that cleaves many membrane substrates including Amyloid Precursor Protein (APP), Notch, E-cadherin, Her4 and CD44. APP is a particularly notable substrate because of its association with Alzheimer disease. Together, gamma-secretase and beta-secre...
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Main Authors: | Gertsik, Natalya, Li, Yue Ming, Chau, De Ming |
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Format: | Conference or Workshop Item |
Language: | English |
Published: |
2016
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Online Access: | http://psasir.upm.edu.my/id/eprint/53874/1/Detection%20of%20active%20site%20conformation%20changes%20of%20gamma-secretase%2C%20a%20key%20enzyme%20associated%20with%20Alzheimer%20disease%2C%20with%20small%20molecules.pdf http://psasir.upm.edu.my/id/eprint/53874/ https://www.frontiersin.org/10.3389/conf.fncel.2016.36.00137/3912/14%3Csup%3Eth%3C_sup%3E_Meeting_of_the_Asian-Pacific_Society_for_Neurochemistry/all_events/event_abstract |
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