Small molecule grp94 inhibitors block dengue and Zika virus replication

• Main Authors: Rothan, Hussin A., Zhong, Yongwang, Sanborn, Mark A., Teoh, Teow Chong, Ruan, Jingjing, Yusof, Rohana, Hang, Jun, Henderson, Mark J., Fang, Shengyun
• Format: Article
• Published: Elsevier Masson 2019
• Subjects: QR Microbiology; R Medicine
• Online Access: http://eprints.um.edu.my/23623/; https://doi.org/10.1016/j.antiviral.2019.104590

Two major flaviviruses, dengue virus (DENV) and Zika virus (ZIKV), cause severe health and economic burdens worldwide. Recently, genome-wide screenings have uncovered the importance of regulators of the Hrd1 ubiquitin ligase-mediated endoplasmic reticulum (ER)-associated degradation (ERAD) pathway f...