β-Mangostin induces p53-dependent G2/M cell cycle arrest and apoptosis through ROS mediated mitochondrial pathway and NfkB suppression in MCF-7 cells

• Main Authors: Syam, Suvitha, Bustamam, Ahmad, Abdullah, Rasedee, Sukari, Mohd Aspollah, Mohd Hashim, Najihah, Ghaderian, Mostafa, Rahmani, Mawardi, Mohan, Syam, Abdelwahab, Siddig Ibrahim, Mohd Ali, Hapipah
• Format: Article
• Language: English
• Published: Elsevier 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/36671/1/%CE%B2.pdf; http://psasir.upm.edu.my/id/eprint/36671/

β-Mangostin (βM) was isolated from Cratoxylum arborescens to investigate its anti-cancer effect in MCF-7 cells. βM induced apoptosis by down-regulation of Bcl2 and up-regulation of Bax, triggering the cytochrome c release from mitochondria to cytosol. The release of caspase-9 and -7 and consequently...