Artonin E induces p53-independent g1 cell cycle arrest and apoptosis through ROS-mediated mitochondrial pathway and livin suppression in MCF-7 cell

• Main Authors: Etti, Imaobong Christopher, Abdullah, Rasedee @ Mat, Mohd Hashim, Najihah, Abdul, Ahmad Bustamam, Kadir, Arifah, Swee, Keong Yeap, Waziri, Peter, Malami, Ibrahim, Kian, Lam Lim, Etti, Christopher J.
• Format: Article
• Language: English
• Published: Dove Medical Press 2017
• Online Access: http://psasir.upm.edu.my/id/eprint/60929/1/Artonin%20E%20induces%20p53-independent%20g1%20cell%20cycle%20arrest%20and%20apoptosis%20through%20ROS-mediated%20mitochondrial%20pathway%20and%20livin%20suppression%20in%20MCF-7%20cell.pdf; http://psasir.upm.edu.my/id/eprint/60929/; https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5367776/pdf/dddt-11-865.pdf

Artonin E is a prenylated flavonoid compound isolated from the stem bark of Artocarpus elasticus. This phytochemical has been previously reported to be drug-like with full compliance to Lipinski's rule of five and good physicochemical properties when compared with 95% of orally available drugs....