β-mangostin suppresses LA-7 cells proliferation in vitro and in vivo: involvement of antioxidant enzyme modulation; suppression of matrix metalloproteinase and α6β4 integrin signalling pathways

• Main Authors: Mohan, Suvitha Syam, Abdul, Ahmad Bustamam, Mohd Hashim, Najihah, Ghaderian, Mostafa, Hobani, Yahya Hasan, Makeen, Anwar, Abdelwahab, Siddig Ibrahim, Mohan, Syam
• Format: Article
• Language: English
• Published: Elsevier 2016
• Online Access: http://psasir.upm.edu.my/id/eprint/43343/1/43343.pdf; http://psasir.upm.edu.my/id/eprint/43343/; http://www.sciencedirect.com/science/article/pii/S1756464616000608

β-mangostin (βM) was isolated from Cratoxylum arborescens to investigate anti-breast cancer effect in vitro and in vivo. βM exhibited an inhibitory effect on the growth of LA-7 cells in vitro with apoptosis formation. In the animal model, βM treatment was found to be effective in improving the tissu...