Typhonium flagelliforme induces apoptosis in CEMss cells via activation of caspase-9, PARP cleavage and cytochrome c release: Its activation coupled with G0/G1 phase cell cycle arrest.

• Main Authors: Mohan, Syam, Abdul, Ahmad Bustaman, Abdelwahab, Siddig Ibrahim, Al-Zubairi, Adel Sharaf, Sukari, Mohamed Aspollah, Abdullah, Rasedee, Elhassan Taha, Manal Mohamed, Ibrahim, Mohamed Yousif, Syam, Suvitha
• Format: Article
• Language: English; English
• Published: 2010 Elsevier Ireland Ltd. All rights reserved 2010
• Online Access: http://psasir.upm.edu.my/id/eprint/9455/1/Typhonium%20flagelliforme%20induces%20apoptosis%20in%20CEMss%20cells%20via%20activation%20of%20caspase.pdf; http://psasir.upm.edu.my/id/eprint/9455/; http://dx.doi.org/10.1016/j.jep.2010.07.043

Ethnopharmacological relevance: The plant Typhonium flagelliforme (TF), commonly known as ‘rodent tuber’ in Malaysia, is often used as traditional remedy for cancer, including leukemia. Aim of the study:Wehad previously identified morphologically that the linoleic acid rich fraction (DCM/F7) from...