Gene network disruptions and neurogenesis defects in the adult Ts1Cje mouse model of Down syndrome

• Main Authors: Hewitt, Chelsee Ann, Ling, King Hwa, Merson, Tobias D., Simpson, Ken M., Ritchie, Matthew E., King, Sarah L., Pritchard, Melanie A., Smyth, Gordon K., Thomas, Tim, Scott, Hamish S., Voss, Anne K.
• Format: Article
• Language: English
• Published: Public Library of Science 2010
• Online Access: http://psasir.upm.edu.my/id/eprint/14865/1/14865.PDF; http://psasir.upm.edu.my/id/eprint/14865/; https://journals.plos.org/plosone/article?id=10.1371/journal.pone.0011561

Background: Down syndrome (DS) individuals suffer mental retardation with further cognitive decline and early onset Alzheimer's disease. Methodology/Principal Findings: To understand how trisomy 21 causes these neurological abnormalities we investigated changes in gene expression networ...