Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors.
The majority of BRCA1-associated breast cancers are basal cell–like, which is associated with a poor outcome. Using a spontaneous mouse mammary tumor model, we show that platinum compounds, which generate DNA breaks during the repair process, are more effective than doxorubicin in Brca1/p53–mutated...
Saved in:
Main Authors: | Shafee, Norazizah, Smith, Christopher R., Shuanzeng, Wel, Yoo, Kim, Mills, Gordo B., Hortobagyi, Gabriel N., Stanbridge, Eric J. |
---|---|
Format: | Article |
Language: | English |
Published: |
American Association for Cancer Research
2008
|
Online Access: | http://psasir.upm.edu.my/id/eprint/13481/ |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Newcastle disease virus degrades HIF-1a through proteasomal pathways independent of VHL and p53
by: Abd Aziz, Noraini, et al.
Published: (2016) -
Surgery for BRCA, TP53 and PALB2: a literature review
by: Song, Chin Vern, et al.
Published: (2018) -
Increased expression of C5a receptor (CD88) mRNA in canine mammary tumors.
by: Mohd Noor, Mohd Hezmee, et al.
Published: (2011) -
Bromelain enhances the anti-tumor effects of cisplatin on 4T1 breast tumor model in vivo
by: Mohamad, Nurul Elyani, et al.
Published: (2019) -
The roles of miRNAs in human breast cancer and canine mammary tumor
by: Yu, Richard Ming Chuan, et al.
Published: (2017)