Cancer stem cells contribute to cisplatin resistance in Brca1/p53-mediated mouse mammary tumors.

• Main Authors: Shafee, Norazizah, Smith, Christopher R., Shuanzeng, Wel, Yoo, Kim, Mills, Gordo B., Hortobagyi, Gabriel N., Stanbridge, Eric J.
• Format: Article
• Language: English
• Published: American Association for Cancer Research 2008
• Online Access: http://psasir.upm.edu.my/id/eprint/13481/

The majority of BRCA1-associated breast cancers are basal cell–like, which is associated with a poor outcome. Using a spontaneous mouse mammary tumor model, we show that platinum compounds, which generate DNA breaks during the repair process, are more effective than doxorubicin in Brca1/p53–mutated...