The oncolytic activity of Newcastle disease virus in clear cell renal carcinoma cells in normoxic and hypoxic conditions: the interplay between von Hippel-Lindau and interferon-β signaling

• Main Authors: Ch'ng, Wei Choong, Stanbridge, Eric J., Yusoff, Khatijah, Shafee, Norazizah
• Format: Article
• Language: English
• Published: Mary Ann Liebert 2013
• Online Access: http://psasir.upm.edu.my/id/eprint/28045/1/28045.pdf; http://psasir.upm.edu.my/id/eprint/28045/; http://online.liebertpub.com/doi/abs/10.1089/jir.2012.0095

Viral-mediated oncolysis is a promising cancer therapeutic approach offering an increased efficacy with less toxicity than the current therapies. The complexity of solid tumor microenvironments includes regions of hypoxia. In these regions, the transcription factor, hypoxia inducible factor (HIF), i...