Cover Image

Formaldehyde-Inactivated Whole-Virus Vaccine Protects a Murine Model of Enterovirus 71 Encephalomyelitis against Disease

Enterovirus 71 (EV71) causes childhood hand, foot, and mouth disease and neurological complications, and no vaccines or therapeutic drugs are currently available. Formaldehyde-inactivated whole-virus vaccines derived from EV71 clinical isolates and a mouse-adapted virus (MAV) were tested in a mouse...

Full description

Saved in:

Bibliographic Details
Main Authors:	Ong, Kien Chai, Devi, Shamala, Cardosa, Mary Jane, Wong, Kum Thong
Format:	E-Article
Language:	English
Published:	American Society for Microbiology 2010
Subjects:	Q Science (General) QR355 Virology R Medicine (General)
Online Access:	http://ir.unimas.my/id/eprint/6978/1/Formaldehyde-Inactivated%20Whole-Virus%20Vaccine%20Protects%20a%20Murine%20Model%20of%20Enterovirus%2071%20Encephalomyelitis%20against%20Disease.pdf http://ir.unimas.my/id/eprint/6978/ http://www.ncbi.nlm.nih.gov/pubmed/?term=19864378
Tags:	Add Tag No Tags, Be the first to tag this record!

Similar Items

Formaldehyde-inactivated whole-virus vaccine protects a murine model of enterovirus 71 encephalomyelitis against disease
by: Ong, K.C., et al.
Published: (2010)

High-titred neutralizing antibodies to human enterovirus 71 preferentially bind to the N-terminal portion of the capsid protein VP1
by: Tan, Cheng Siang, et al.
Published: (2007)

Development of novel vaccines against Enterovirus-71
by: Yee, Isabel Pin Tsin *, et al.
Published: (2015)

Development of live attenuated Enterovirus 71 vaccine strains that confer protection against lethal challenge in mice
by: Yee, Isabel Pin Tsin *, et al.
Published: (2019)

Flavonoids as antiviral agents for Enterovirus A71 (EV-A71)
by: Lalani, S.*, et al.
Published: (2020)

The impact of spontaneous mutations of Enterovirus 71 (EV-A71) on virulence.
by: Mandary, Madiha Bibi
Published: (2020)

T Cell immunity to enterovirus 71 infection in humans and implications for vaccine development
by: Yee, Isabel Pin Tsin *, et al.
Published: (2018)

Impact of genetic changes in the Enterovirus 71 genome on virulence
by: Poh, Chit Laa *, et al.
Published: (2019)

Impact of genetic changes, pathogenicity and antigenicity on Enterovirus- A71 vaccine development
by: Yee, Isabel Pin Tsin *, et al.
Published: (2017)

Clinical features, diagnosis, and management of enterovirus 71
by: Ooi, Mong How, et al.
Published: (2010)

Enterovirus 71 encephalomyelitis and Japanese encephalitis can be distinguished by topographic distribution of inflammation and specific intraneuronal detection of viral antigen and RNA
by: Wong, K.T., et al.
Published: (2012)

Functional insights into Silymarin as an antiviral agent against Enterovirus A71 (EV-A71)
by: Lalani, S.*, et al.
Published: (2021)

Molecular docking of SP40 peptide towards cellular receptors for enterovirus 71 (EV-A71)
by: Masomian, Malihe *, et al.
Published: (2021)

Virology, epidemiology, pathogenesis, and control of enterovirus 71.
by: Solomon, Tom, et al.
Published: (2010)

A generic assay for whole-genome amplification and deep sequencing of enterovirus A71
by: Tan, Le Van, et al.
Published: (2015)

Development of novel miRNA-based vaccines and antivirals against Enterovirus 71
by: Yee, Isabel Pin Tsin *, et al.
Published: (2016)

Pluripotent human embryonic stem cell derived neural lineages for in vitro modelling of enterovirus 71 infection and therapy
by: Yap, May Shin *, et al.
Published: (2016)

Molecular mechanism of L-SP40 peptide and in vivo efficacy against EV-A71 in neonatal mice
by: Lalani, Salima, et al.
Published: (2021)

Isolation of subgenus B adenovirus during a fatal outbreak of enterovirus 71-associated hand, foot, and mouth disease in Sibu, Sarawak.
by: Cardosa, Mary Jane, et al.
Published: (1999)

A decade of sustained selection pressure on two surface sites of the VP1 protein of Enterovirus A71 suggests that immune evasion may be an indirect driver for virulence
by: Roberts, Ryan, et al.
Published: (2019)

Development of a multiplex polymerase chain reaction assay for simultaneous identification of human enterovirus 71 and coxsackievirus A16.
by: Thao, Nguyen Thi Thanh, et al.
Published: (2010)

A Virological Study of Enterovirus Infections in Peninsular Malaysia
by: Samuel, L., et al.
Published: (2008)

Insights into innate and adaptive immune responses in vaccine development against EV-A71
by: Lim, Hui Xuan *, et al.
Published: (2019)

Characterization of Antiviral Peptide SP40 and its analogues against Enterovirus A71
by: Abd Khalid, Faisal Zarif
Published: (2021)

Novel Multiplex Oligonucleotide-Conjugated Bead Suspension Array for Rapid Identification of Enterovirus 71 Subgenogroups
by: Wu, Y., et al.
Published: (2011)

A monoclonal antibody to ameliorate central nervous system infection and improve survival in a murine model of human Enterovirus-A71 encephalomyelitis
by: Soon, Hao Tan, et al.
Published: (2016)

Antiviral activity of silymarin in comparison with baicalein against EV-A71
by: Lalani, S.*, et al.
Published: (2020)

Characterization of plaque variants and the involvement of Quasi-Species in a population of EV-A71
by: Mandary, M. B. *, et al.
Published: (2020)

Dengue vaccine design : issues and challenges
by: Cardosa, Mary Jane
Published: (1998)

EV71 may not be cause of HFM
by: Divakaran, Vinod
Published: (2000)

Validation and utilization of an internally controlled multiplex Real-time RT-PCR assay for simultaneous detection of enteroviruses and enterovirus A71 associated with hand foot and mouth disease
by: Thanh, Tran Tan, et al.
Published: (2015)

Whole genome sequence analysis showing unique SARS-CoV-2 lineages of B.1.524 and AU.2 in Malaysia
by: Zainulabid, Ummu Afeera, et al.
Published: (2022)

RSAD2 and AIM2 modulateCV-A16 and EV-A71 replication in neuronal cells in different ways that may be associated with their 5′ non-translated regions
by: David, Perera
Published: (2017)

Nanomaterials aspects for photocatalysis as potential for the inactivation of COVID-19 virus
by: Bagheri, Samira, et al.
Published: (2023)

In Enterovirus 71 Encephalitis With Cardio-Respiratory Compromise, Elevated Interleukin 1β, Interleukin 1 Receptor Antagonist, and Granulocyte Colony-Stimulating Factor Levels Are Markers of Poor Prognosis
by: Griffiths, Michael J., et al.
Published: (2012)

Dengue haemorrhagic fever: questions of pathogenesis.
by: Cardosa, Mary Jane
Published: (2000)

Viral transmission, neuropathogenesis and therapeutic antibody studies in a murine model of enterovirus 71 encephalomyelitis / Tan Soon Hao
by: Tan, Soon Hao
Published: (2017)

Substitution of Coxsackievirus A16 VP1 BC and EF Loop Altered the Protective Immune Responses in Chimera Enterovirus A71
by: Xiu Hui, Tan, et al.
Published: (2023)

Isolation and identification of inter-species enterovirus recombinant genomes
by: Bentley, Kirsten, et al.
Published: (2021)

EV71 may be agent of death
by: Chok, Suat Ling, et al.
Published: (2000)