Formaldehyde-Inactivated Whole-Virus Vaccine Protects a Murine Model of Enterovirus 71 Encephalomyelitis against Disease

• Main Authors: Ong, Kien Chai, Devi, Shamala, Cardosa, Mary Jane, Wong, Kum Thong
• Format: E-Article
• Language: English
• Published: American Society for Microbiology 2010
• Subjects: Q Science (General); QR355 Virology; R Medicine (General)
• Online Access: http://ir.unimas.my/id/eprint/6978/1/Formaldehyde-Inactivated%20Whole-Virus%20Vaccine%20Protects%20a%20Murine%20Model%20of%20Enterovirus%2071%20Encephalomyelitis%20against%20Disease.pdf; http://ir.unimas.my/id/eprint/6978/; http://www.ncbi.nlm.nih.gov/pubmed/?term=19864378

Enterovirus 71 (EV71) causes childhood hand, foot, and mouth disease and neurological complications, and no vaccines or therapeutic drugs are currently available. Formaldehyde-inactivated whole-virus vaccines derived from EV71 clinical isolates and a mouse-adapted virus (MAV) were tested in a mouse...