Substitution of Coxsackievirus A16 VP1 BC and EF Loop Altered the Protective Immune Responses in Chimera Enterovirus A71

• Main Authors: Xiu Hui, Tan, Wei Lim, Chong, Vannajan Sanghiran, Lee, Syahril, Abdullah, Kartini, Jasni, Saiful Qushairi, Suarni, David, Perera, I Ching, Sam, Yoke Fun, Chan
• Format: Article
• Language: English
• Published: MDPI 2023
• Subjects: Q Science (General); QR355 Virology; R Medicine (General)
• Online Access: http://ir.unimas.my/id/eprint/43593/3/Substitution.pdf; http://ir.unimas.my/id/eprint/43593/; https://www.mdpi.com/2076-393X/11/8/1363; https://doi.org/10.3390/vaccines11081363

Hand, foot and mouth disease (HFMD) is a childhood disease caused by enterovirus A71 (EV-A71) and coxsackievirus A16 (CV-A16). Capsid loops are important epitopes for EV-A71 and CV-A16. Seven chimeric EV-A71 (ChiE71) involving VP1 BC (45.5% similarity), DE, EF, GH and HI loops, VP2 EF loop and VP3 G...