Identification of cancer inhibitors from Hystrix brachyura bezoar extracts using LC-MS multivariate data analysis and in silico evaluation on Bcl-2, cyclin B/CDK1, VEGF and NM23-H1

• Main Authors: Al’ aina Yuhainis Firus Khan, Qamar Uddin Ahmed, Alfi Khatib, Zalikha Ibrahim, Tanzina Sharmin Nipun, Hatim Abdullah Natto, Mohd Zuwairi Saiman, Zainul Amiruddin Zakaria, Ridhwan Abdul Wahab
• Format: Article
• Language: English; English
• Published: Blacpma 2024
• Subjects: QD1-999 Chemistry; RS400-431 Pharmaceutical chemistry
• Online Access: https://eprints.ums.edu.my/id/eprint/38589/1/ABSTRACT.pdf; https://eprints.ums.edu.my/id/eprint/38589/2/FULL%20TEXT.pdf; https://eprints.ums.edu.my/id/eprint/38589/; https://doi.org/10.37360/blacpma.24.23.1.4

Hystrix brachyura bezoar is calcified undigested material found in the gastrointestinal tract known for various medicinal benefits including as an anticancer agent. However, the H. brachyura population has been declining due to its demand and is under Malaysian law protection. Therefore, present stu...