Potential anticancer agents identification of Hystrix Brachyura Bezoar through gas chromatography-mass spectrometry-based metabolomics and protein-ligand interaction with molecular docking analyses

• Main Authors: Firus Khan, Al'aina Yuhainis, Abdul Wahab, Ridhwan, Ahmed, Qamar Uddin, Khatib, Alfi, Ibrahim, Zalikha, Nipun, Tanzina Sharmin, Nawawi, Hapizah, Hejaz Azmi, Syed Najmul, Islam Sarker, Md. Zaidul, Zakaria, Zainul Amiruddin, Alkahtani, Saad, A. AlKahtane, Abdullah
• Format: Article
• Language: English; English
• Published: Elsevier 2023
• Subjects: QD Chemistry; RM Therapeutics. Pharmacology
• Online Access: http://irep.iium.edu.my/105204/13/105204_Potential%20anticancer%20agents%20identification%20of%20Hystrix%20Brachyura%20Bezoar_SCOPUS.pdf; http://irep.iium.edu.my/105204/14/105204_Potential%20anticancer%20agents%20identification%20of%20Hystrix%20Brachyura%20Bezoar.pdf; http://irep.iium.edu.my/105204/; https://www.sciencedirect.com/science/article/pii/S1018364723001891/pdfft?md5=0f8b2e86041787d574d6332df9cd9a42&pid=1-s2.0-S1018364723001891-main.pdf; https://doi.org/10.1016/j.jksus.2023.102727

Background: Bezoar (PB) is a rare, solidified form of undigested food commonly found in the gastrointestinal tract of porcupine (Hystrix brachyura). It is believed to be traditionally used to treat various diseases including different kinds of cancers in Malaysia. However, its active principles have...