Identification of cancer inhibitors from Hystrix brachyura bezoar extracts using LC-MS multivariate data analysis and in silico evaluation on Bcl-2, cyclin B/CDK1, VEGF and NM23-H1

• Main Authors: Firus Khan, Al’ aina Yuhainis, Ahmed, Qamar Uddin, Khatib, Alfi, Ibrahim, Zalikha, Nipun, Tanzina Sharmin, Natto, Hatim A., Saiman, Mohd Zuwairi, Zakaria, Zainul Amiruddin, Abdul Wahab, Ridhwan
• Format: Article
• Language: English; English
• Published: MS-Editions 2024
• Subjects: QD Chemistry; RM Therapeutics. Pharmacology; RS403 Materia Medica-Pharmaceutical Chemistry
• Online Access: http://irep.iium.edu.my/107899/3/107899_Identification%20of%20cancer%20inhibitors%20from%20Hystrix%20brachyura%20bezoar.pdf; http://irep.iium.edu.my/107899/9/107899_Identification%20of%20cancer%20inhibitors%20from%20Hystrix%20brachyura%20bezoar_SCOPUS.pdf; http://irep.iium.edu.my/107899/; http://www.blacpma.ms-editions.cl/; https://doi.org/10.37360/blacpma.24.23.1.4

Hystrix brachyura bezoar is calcified undigested material found in the gastrointestinal tract known for various medicinal benefits including as an anticancer agent. However, the H. brachyura population has been declining due to its demand and is under Malaysian law...