Synthesis of N'-Substituted-2-((5-(4-Chlorophenyl)-1,3,4-Oxadiazol-2-ylthio Acetohydrazie Derivatives as Suitable Antibacterial Agents

• Main Authors: Akhtar, Muhammad Nadeem, Rasool, Shahid, Rehman, Aziz-ur, Abbasi, Muhammad Athar
• Format: Article
• Language: English
• Published: Pharmacotherapy Group 2015
• Subjects: QD Chemistry
• Online Access: http://umpir.ump.edu.my/id/eprint/7997/1/fist-2015-nadeem-Synthesis%20of%20N-Substituted.pdf; http://umpir.ump.edu.my/id/eprint/7997/; http://www.ajol.info/index.php/tjpr/article/view/119561

Purpose: To evaluate antibacterial activity of a series of molecules bearing 1,3,4-oxadiazole and azomethine moieties. Methods: The 4-chlorobenzoic acid (1) was precursor to N'-substituted-2-(5-(4-chlorophenyl)-1,3,4- oxadiazol-2-ylthio)acetohydrazide, 8a-p, through a multistep synthesis of co...