Synthesis of chromen-4-one-oxadiazole substituted analogs as potent β-glucuronidase inhibitors

• Main Authors: Taha, Muhammad, Rahim, Fazal, Ali, Muhammad, Khan, Muhammad Naseem, Alqahtani, Mohammed A., Bamarouf, Yasser A., Gollapalli, Mohammed, Farooq, Rai Khalid, Shah, Syed Adnan Ali, Ahmed, Qamar Uddin, Zakaria, Zainul Amiruddin
• Format: Article
• Language: English
• Published: MDPI 2019
• Online Access: http://psasir.upm.edu.my/id/eprint/38388/1/38388.pdf; http://psasir.upm.edu.my/id/eprint/38388/; https://www.mdpi.com/1420-3049/24/8/1528

Chromen-4-one substituted oxadiazole analogs 1–19 have been synthesized, characterized and evaluated for β-glucuronidase inhibition. All analogs exhibited a variable degree of β-glucuronidase inhibitory activity with IC50 values ranging in between 0.8 ± 0.1–42.3 ± 0.8 μM when compared with the stand...