Synthesis Pharmacological Evaluation, Molecular Docking And Cytotoxicty Studies On Some N-Substituted 5-[(4-Chlorophenoxy)Methyl]-1,3,4-Oxadiazole-2yl-2-Sulfanyl Acetamides

• Main Authors: Siddiqui, Sabahat Zahra, Abbasi, Muhammad Athar, Rehman, Aziz-ur, Irshad, Misbah, Shahzad, Babar, Mohd Ashraf, Ahmad, Ahmad, Irshad, Lodhi, Muhammad A., Mirza, Bushra, Ismail, Hammad, Akhtar, Muhammad Nadeem
• Format: Article
• Language: English
• Published: IndianScience.in 2014
• Subjects: QD Chemistry
• Online Access: http://umpir.ump.edu.my/id/eprint/7988/1/fist-2014-nadeem-synthesis_pharmacological.pdf; http://umpir.ump.edu.my/id/eprint/7988/; https://iajpr.com/archive/volume-4/august-2014#

The framework of our systematic efforts focuses on the synthesis of N-substituted 5-[(4-chlorophenoxy) methyl]-1,3,4-oxadiazole-2yl-2-sulfanyl acetamides. 4-Chlorophenoxyacetic acid (1) was utilized as a precursor for the synthesis of parent 1,3,4-oxadiazole moiety. Esterification of 1in the presenc...