Convergent synthesis of new N -substituted 2-{[5-(1H -indol-3-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl} acetamides as suitable therapeutic agents

• Main Authors: Rubab, Kaniz, Abbasi, Muhammad Athar, Ur-Rehman, Aziz, Siddiqui, Sabahat Zahra, Ashraf, Muhammad, Shaukat, Ayesha, Ahmad, Irshad, Lodhi, Muhammad A., Khan, Farman Ali, Shahid, Muhammad, Akhtar, Muhammad Nadeem
• Format: Article
• Language: English
• Published: Faculdade de Ciencias Farmaceuticas (Biblioteca) 2015
• Subjects: QD Chemistry; TP Chemical technology
• Online Access: http://umpir.ump.edu.my/id/eprint/29801/1/Convergent%20synthesis%20of%20new%20N%20-substituted%202.pdf; http://umpir.ump.edu.my/id/eprint/29801/; https://doi.org/10.1590/S1984-82502015000400019; https://doi.org/10.1590/S1984-82502015000400019

A series of N-substituted 2-{[5-(1H-indol-3-ylmethyl)-1,3,4-oxadiazol-2-yl]sulfanyl} acetamides (8a-w) was synthesized in three steps. The first step involved the sequential conversion of 2-(1H-indol-3-yl) acetic acid (1) to ester (2) followed by hydrazide (3) formation and finally cyclization in th...