Surface peptide functionalization of zeolitic imidazolate framework-8 for autonomous homing and enhanced delivery of chemotherapeutic agent to lung tumor cells

• Main Authors: Nurul Akmarina, Mohd Abdul Kamal, Emilia, Abdulmalek, Sharida, Fakurazi, Cordova, Kyle E., Mohd Basyaruddin, Abdul Rahman
• Format: Article
• Language: English; English
• Published: Royal Society of Chemistry 2021
• Subjects: Q Science (General); RC Internal medicine; TP Chemical technology
• Online Access: http://umpir.ump.edu.my/id/eprint/43164/1/Surface%20peptide%20functionalization%20of%20zeolitic%20imidazolate%20framework-8%20for%20autonomous%20homing_ABST.pdf; http://umpir.ump.edu.my/id/eprint/43164/2/Surface%20peptide%20functionalization%20of%20zeolitic%20imidazolate%20framework-8%20for%20autonomous%20homing.pdf; http://umpir.ump.edu.my/id/eprint/43164/; https://doi.org/10.1039/D1DT00116G; https://doi.org/10.1039/D1DT00116G

Chemotherapeutic agents used in treating certain cancer types operate in a non-selective manner tending to accumulate in normal, healthy tissue when high doses are used. To mitigate the toxicity effect resulting from this, there is an urgent need to develop active nano delivery systems capable of re...