Overview of the multifaceted resistances toward EGFR-TKIs and new chemotherapeutic strategies in non-small cell lung cancer

• Main Authors: Dzulkeflee, Rashidi, Leong, Kok Hoong, Ogawa, Satoshi, Bignon, Jerome, Chan, Mun Chiang, Kong, Kin Weng
• Format: Article
• Published: Elsevier 2022
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/40814/

The role of epidermal growth factor receptor (EGFR) in non-small cell lung cancer (NSCLC) has been vastly studied over the last decade. This has led to the rapid development of many generations of EGFR tyrosine kinase inhibitors (EGFR-TKIs). However, patients treated with third-generation TKIs (osim...