Myeloma-induced alloreactive T cells arising in Myeloma-infiltrated bones include double-positive CD8(+)CD4(+) T cells: evidence from myeloma-bearing mouse model

• Main Authors: Freeman, L.M., Lam, A., Petcu, E., Smith, R., Salajegheh, A., Diamond, P., Zannettino, A., Evdokiou, A., Luff, J., Wong, P.F., Khalil, D., Waterhouse, N., Vari, F., Rice, A.M., Catley, L., Hart, D.N.J., Vuckovic, S.
• Format: Article
• Language: English
• Published: 2011
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/8534/1/Myeloma-induced_alloreactive_t-cells.pdf; http://eprints.um.edu.my/8534/; http://www.jimmunol.org/content/187/8/3987.full.pdf

The graft-versus-myeloma (GVM) effect represents a powerful form of immune attack exerted by alloreactive T cells against multiple myeloma cells, which leads to clinical responses in multiple myeloma transplant recipients. Whether myeloma cells are themselves able to induce alloreactive T cells capa...