Polymorphisms in the CD14 and TLR4 genes independently predict CD4+ T-cell recovery in HIV-infected individuals on antiretroviral therapy

• Main Authors: Yong, Y.K., Shankar, E.M., Solomon, A., Spelman, T., Fairley, C.K., Elliott, J.H., Hoy, J., Cameron, P.U., Kamarulzaman, A., Lewin, S.R.
• Format: Article
• Published: Lippincott, Williams & Wilkins 2016
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/18760/; http://dx.doi.org/10.1097/QAD.0000000000001179

Background: Chronic HIV infection leads to marked depletion of CD4+ T cells in the gastrointestinal tract and increased microbial translocation measured by an increase in circulating lipopolysaccharide (LPS) levels. Here, we hypothesized that single-nucleotide polymorphisms (SNPs) in genes encoding...