Suppression of apoptosis in perfusion culture of Myeloma NS0 cells enhances cell growth but reduces antibody productivity
A spin filter perfusion systems was used to achieve a high cell density culture for two NS0 cell lines in 2 litres bioreactors. One cell line is transfected with the bcl-2 gene (NS0 Bcl-2) encodes the 'anti-apoptotic' human Bcl-2 protein and the other cell line (NS0 Control) with a blank v...
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| Main Authors: | , |
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| Format: | Article |
| Language: | English English |
| Published: |
Kluwer Academic Publishers
2004
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| Online Access: | http://psasir.upm.edu.my/id/eprint/18402/1/Suppression%20of%20apoptosis%20in%20perfusion%20culture%20of%20Myeloma%20NS0%20cells%20enhances%20cell%20growth%20but%20reduces%20antibody%20productivity.pdf http://psasir.upm.edu.my/id/eprint/18402/ http://dx.doi.org/10.1023/B:APPT.0000045792.63249.5a |
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http://psasir.upm.edu.my/id/eprint/18402/1/Suppression%20of%20apoptosis%20in%20perfusion%20culture%20of%20Myeloma%20NS0%20cells%20enhances%20cell%20growth%20but%20reduces%20antibody%20productivity.pdfhttp://psasir.upm.edu.my/id/eprint/18402/
http://dx.doi.org/10.1023/B:APPT.0000045792.63249.5a