Small interfering RNA silencing of interleukin-6 in mesenchymal stromal cells inhibits multiple myeloma cell growth

• Main Authors: Teoh, Hoon Koon, Chong, Pei Pei, Abdullah, Maha, Sekawi, Zamberi, Tan, Geok Chin, Leong, Chooi Fun, Cheong, Soon Keng
• Format: Article
• Language: English
• Published: Elsevier 2016
• Online Access: http://psasir.upm.edu.my/id/eprint/53832/1/Small%20interfering%20RNA%20silencing%20of%20interleukin-6%20in%20mesenchymal%20stromal%20cells%20inhibits%20multiple%20myeloma%20cell%20growth.pdf; http://psasir.upm.edu.my/id/eprint/53832/; http://www.lrjournal.com/article/S0145-2126(15)30396-9/fulltext

Studies demonstrated that mesenchymal stromal cells (MSC) from bone marrow stroma produced high concentration of interleukin-6 (IL-6) that promoted multiple myeloma cell growth. In view of the failure of IL-6 monoclonal antibody therapy to demonstrate substantial clinical responses in early clinical...