Cucurbitacin L 2-O-β-Glucoside demonstrates apoptogenesis in colon adenocarcinoma cells (HT-29): involvement of reactive oxygen and nitrogen species regulation

• Main Authors: Abdelwahab, S.I., Hassan, L.E., Abdul Majid, A.M., Yagi, S.M., Mohan, S., Elhassan Taha, M.M., Ahmad, S., Chuen, C.S., Narrima, P., Rais, M.M., Syam, S., Moharam, B.A., Hadi, A.H.
• Format: Article
• Language: English
• Published: Hindawi 2012
• Subjects: RS Pharmacy and materia medica
• Online Access: http://eprints.um.edu.my/3309/1/1.pdf; http://eprints.um.edu.my/3309/; https://doi.org/10.1155/2012/490136

Emerging evidence suggests that reactive oxygen (ROS) and nitrogen (RNS) species can contribute to diverse signalling pathways of inflammatory and tumour cells. Cucurbitacins are a group of highly oxygenated triterpenes. Many plants used in folk medicine to treat cancer have been found to contain cu...