α-Mangostin from Cratoxylum arborescens demonstrates apoptogenesis in MCF-7 with regulation of NF-κB and Hsp70 protein modulation in vitro, and tumor reduction in vivo

• Main Authors: Ibrahim, Mohamed Yousif, Mohd Hashim, Najihah, Mohan, Syam, Abdulla, Mahmood Ameen, Kamalidehghan, Behnam, Ghaderian, Mostafa, Dehghan, Firouzeh, Ali, Landa Zeenelabdin, Arbab, Ismail Adam, Yahayu, Maizatulakmal, Ee, Gwendoline Cheng Lian, Ahmadipour, Fatemeh, Mohd Ali, Hapipah
• Format: Article
• Language: English
• Published: Dove Medical Press 2014
• Online Access: http://psasir.upm.edu.my/id/eprint/36367/1/%CE%B1.pdf; http://psasir.upm.edu.my/id/eprint/36367/; http://www.dovepress.com/alpha-mangostin-from-cratoxylum-arborescens-demonstrates-apoptogenesis-peer-reviewed-article-DDDT

Cratoxylum arborescens is an equatorial plant belonging to the family Guttiferae. In the current study, α-Mangostin (AM) was isolated and its cell death mechanism was studied. HCS was undertaken to detect the nuclear condensation, mitochondrial membrane potential, cell permeability, and the release...