Cucurbitacin L 2-O-β-Glucoside Demonstrates Apoptogenesis in Colon Adenocarcinoma Cells (HT-29): Involvement of Reactive Oxygen and Nitrogen Species Regulation

• Main Authors: Abdelwahab, Siddig Ibrahim, Hassan, Loiy Elsir Ahmed, Abdul Majid, Amin M. S., Ahmed Yagi, Sakina M., Mohan, Syam, Mohamed Elhassan Taha, Manal, Ahmad, Syahida, Shiau Chuen, Cheah, Mohd Fauzi, Putri Narrima, Rais, Mohd Mustafa, Syam, Suvitha, Abdulkarim Moharam, Bushra, A. Hadi, A. Hamid
• Format: Article
• Language: English
• Published: Hindawi Publishing Corporation 2012
• Subjects: RM Therapeutics. Pharmacology; RS1-441 Pharmacy and materia medica
• Online Access: http://eprints.usm.my/38597/1/Cucurbitacin_L_2-O-%CE%B2-Glucoside_Demonstrates_Apoptogenesis_in_Colon_Adenocarcinoma_Cells.pdf; http://eprints.usm.my/38597/; https://doi.org/10.1155/2012/490136

Emerging evidence suggests that reactive oxygen (ROS) and nitrogen (RNS) species can contribute to diverse signalling pathways of inflammatory and tumour cells. Cucurbitacins are a group of highly oxygenated triterpenes. Many plants used in folk medicine to treat cancer have been found to contain...