Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii

• Main Authors: Nugroho, Alfarius Eko, Zhang, Wenjia, Hirasawa, Yusuke, Tang, Yiming, Wong, Chin Piow, Kaneda, Toshio, A. Hadi, A. Hamid, Morita, Hiroshi
• Format: Article
• Published: American Chemical Society 2018
• Subjects: Q Science (General); QD Chemistry
• Online Access: http://eprints.um.edu.my/21094/; https://doi.org/10.1021/acs.jnatprod.8b00749

Three new bisindole alkaloids, bisleuconothines B-D (1-3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-...