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Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii

Three new bisindole alkaloids, bisleuconothines B-D (1-3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-...

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Bibliographic Details
Main Authors: Nugroho, Alfarius Eko, Zhang, Wenjia, Hirasawa, Yusuke, Tang, Yiming, Wong, Chin Piow, Kaneda, Toshio, A. Hadi, A. Hamid, Morita, Hiroshi
Format: Article
Published: American Chemical Society 2018
Subjects:
Q Science (General)
QD Chemistry
Online Access:http://eprints.um.edu.my/21094/
https://doi.org/10.1021/acs.jnatprod.8b00749
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Summary:Three new bisindole alkaloids, bisleuconothines B-D (1-3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-16-C-10′ and C-2-O-C-9′. All compounds were deemed noncytotoxic (IC50 > 10 μM) when tested against A549 human lung adenocarcinoma cells.

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