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Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii

Three new bisindole alkaloids, bisleuconothines B-D (1-3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-...

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Main Authors: Nugroho, Alfarius Eko, Zhang, Wenjia, Hirasawa, Yusuke, Tang, Yiming, Wong, Chin Piow, Kaneda, Toshio, A. Hadi, A. Hamid, Morita, Hiroshi
Format: Article
Published: American Chemical Society 2018
Subjects:
Q Science (General)
QD Chemistry
Online Access:http://eprints.um.edu.my/21094/
https://doi.org/10.1021/acs.jnatprod.8b00749
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spelling my.um.eprints.210942021-09-02T04:24:15Z http://eprints.um.edu.my/21094/ Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii Nugroho, Alfarius Eko Zhang, Wenjia Hirasawa, Yusuke Tang, Yiming Wong, Chin Piow Kaneda, Toshio A. Hadi, A. Hamid Morita, Hiroshi Q Science (General) QD Chemistry Three new bisindole alkaloids, bisleuconothines B-D (1-3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-16-C-10′ and C-2-O-C-9′. All compounds were deemed noncytotoxic (IC50 > 10 μM) when tested against A549 human lung adenocarcinoma cells. American Chemical Society 2018 Article PeerReviewed Nugroho, Alfarius Eko and Zhang, Wenjia and Hirasawa, Yusuke and Tang, Yiming and Wong, Chin Piow and Kaneda, Toshio and A. Hadi, A. Hamid and Morita, Hiroshi (2018) Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii. Journal of Natural Products, 81 (11). pp. 2600-2604. ISSN 0163-3864 https://doi.org/10.1021/acs.jnatprod.8b00749 doi:10.1021/acs.jnatprod.8b00749
institution Universiti Malaya
building UM Library
collection Institutional Repository
continent Asia
country Malaysia
content_provider Universiti Malaya
content_source UM Research Repository
url_provider http://eprints.um.edu.my/
topic Q Science (General)
QD Chemistry
spellingShingle Q Science (General)
QD Chemistry
Nugroho, Alfarius Eko
Zhang, Wenjia
Hirasawa, Yusuke
Tang, Yiming
Wong, Chin Piow
Kaneda, Toshio
A. Hadi, A. Hamid
Morita, Hiroshi
Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii
description Three new bisindole alkaloids, bisleuconothines B-D (1-3), were isolated from the bark of Leuconotis griffithii. Their structures were elucidated by 1D and 2D NMR spectroscopy and DFT calculations. Bisleuconothine B (1) is the first monoterpene indole alkaloid dimer featuring bridges between both C-16-C-10′ and C-2-O-C-9′. All compounds were deemed noncytotoxic (IC50 > 10 μM) when tested against A549 human lung adenocarcinoma cells.
format Article
author Nugroho, Alfarius Eko
Zhang, Wenjia
Hirasawa, Yusuke
Tang, Yiming
Wong, Chin Piow
Kaneda, Toshio
A. Hadi, A. Hamid
Morita, Hiroshi
author_facet Nugroho, Alfarius Eko
Zhang, Wenjia
Hirasawa, Yusuke
Tang, Yiming
Wong, Chin Piow
Kaneda, Toshio
A. Hadi, A. Hamid
Morita, Hiroshi
author_sort Nugroho, Alfarius Eko
title Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii
title_short Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii
title_full Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii
title_fullStr Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii
title_full_unstemmed Bisleuconothines B–D, Modified Eburnane–Aspidosperma Bisindole Alkaloids from Leuconotis griffithii
title_sort bisleuconothines b–d, modified eburnane–aspidosperma bisindole alkaloids from leuconotis griffithii
publisher American Chemical Society
publishDate 2018
url http://eprints.um.edu.my/21094/
https://doi.org/10.1021/acs.jnatprod.8b00749
_version_ 1710675847998865408
score 13.214268

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