Nutlin-3 sensitizes nasopharyngeal carcinoma cells to cisplatin-induced cytotoxicity
The small-molecule inhibitor of p53-Mdm2 interaction, Nutlin-3, is known to be effective against cancers expressing wild-type (wt) p53. p53 mutations are rare in nasopharyngeal carcinoma (NPC), hence targeting disruption of p53-Mdm2 interaction to reactivate p53 may offer a promising therapeutic str...
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Main Authors: | Voon, Y.L., Ahmad, M., Wong, P.F., Husaini, R., Ng, W.T.W., Leong, C.O., Lane, D.P., Khoo, A.S.B. |
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Format: | Article |
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Spandidos Publications
2015
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Online Access: | http://eprints.um.edu.my/19489/ http://dx.doi.org/10.3892/or.2015.4177 |
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