Mitochondrial DNA quantity changes in leucocytes of cancer patients on cisplatin and 5-fluorouracil regimen

• Main Authors: Khaing, Ei Phyo, Tun, Aung Win, Lertrit, Patcharee, Suthammarak, Wichit, Kaewsutth, Supannee, Kyaw, May Pyone
• Format: Article
• Language: English
• Published: Institut Perubatan dan Pergigian Termaju (IPPT),Universiti Sains Malaysia 2016
• Subjects: RM Therapeutics. Pharmacology; RM300 Drugs and their action
• Online Access: http://irep.iium.edu.my/54969/12/54969_Mitochondrial%20DNA.pdf; http://irep.iium.edu.my/54969/; http://apps.amdi.usm.my/journal/index.php/jbcs/issue/view/Vol%201%2C%20No%201%2C%20Dec%202016%20-%20Special%20Issue

Purpose: Cisplatin and 5-Fluorouracil are the critical components of therapeutic regimen in a broad range of malignancies. Their therapeutic efficacy is limited due to the development of toxic side effects and drug resistance by the cancer cells. Cisplatin toxic side effects are usually associated w...