Application of champedak mannose-binding lectin in the glycoproteomic profiling of serum samples unmasks reduced expression of alpha-2 macroglobulin and complement factor B in patients with nasopharyngeal carcinoma

• Main Authors: Seriramalu, R., Pang, W.W., Jayapalan, J.J., Mohamed, E., Abdul-Rahman, P.S., Bustam, A.Z., Khoo, A.S.B., Hashim, Onn Haji
• Format: Article
• Language: English
• Published: 2010
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/3431/1/Application_of_champedak_mannose-binding_lectin_in_the_glycoproteomic_profiling_of_serum_samples.pdf; http://eprints.um.edu.my/3431/; http://onlinelibrary.wiley.com/doi/10.1002/prca.201090090/full

The use of lectin affinity chromatography prior to 2-DE separation forms an alternative method to unmask the expression of targeted glycoproteins of lower abundance in serum samples. Reduced expression of alpha-2 macroglobulin (AMG) and complement factor B (CFB) was detected in sera of patients with...