Down-regulation of LPA receptor 5 contributes to aberrant LPA signalling in EBV-associated nasopharyngeal carcinoma

• Main Authors: Yap, L.F., Velapasamy, S., Lee, H.M., Thavaraj, S., Rajadurai, P., Wei, W.B., Vrzalikova, K., Ibrahim, M.H., Khoo, A.S.B., Tsao, S.W., Paterson, I.C., Taylor, G.S., Dawson, C.W., Murrray, P.G.
• Format: Article
• Language: English
• Published: John Wiley & Sons 2015
• Subjects: RK Dentistry
• Online Access: http://eprints.um.edu.my/12916/1/Down-regulation_of_LPA_receptor_5_contributes_to_aberrant_LPA_signalling_in_EBV-associated_nasopharyngeal_carcinoma.pdf; http://eprints.um.edu.my/12916/; http://onlinelibrary.wiley.com/doi/10.1002/path.4460/abstract

Undifferentiated nasopharyngeal carcinoma (NPC) is a highly metastatic disease that is consistently associated with Epstein-Barr virus (EBV) infection. In this study, we have investigated the contribution of lysophosphatidic acid (LPA) signalling to the pathogenesis of NPC. Here we demonstrate two d...