Beta-Lactam Infusion in Severe Sepsis (BLISS): a prospective, two-centre, open-labelled randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis

• Main Authors: Abdul-Aziz, M.H., Sulaiman, H., Mat-Nor, M.B., Rai, V., Wong, K.K., Hasan, M.S., Abd Rahman, A.N., Jamal, J.A., Wallis, S.C., Lipman, J., Staatz, C.E., Roberts, J.A.
• Format: Article
• Published: Springer Verlag (Germany) 2016
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/17981/; http://dx.doi.org/10.1007/s00134-015-4188-0

Purpose: This study aims to determine if continuous infusion (CI) is associated with better clinical and pharmacokinetic/pharmacodynamic (PK/PD) outcomes compared to intermittent bolus (IB) dosing in critically ill patients with severe sepsis. Methods: This was a two-centre randomised controlled tri...