The BLISS study: Beta-Lactam infusion in severe sepsis-randomised controlled trial of continuous versus intermittent beta-lactam infusion in critically ill patients with severe sepsis in a Malaysian ICU setting

• Main Authors: Abdul Aziz, Mohd. Hafiz, Sulaiman, Helmi, Mat Nor, Mohd Basri, Rai, Vineya, Wong, K., Hasan, Mohd Shahnaz, Wallis, Steven C, Lipman, Jeffrey, Staatz, Christine E., Roberts, Jason A.
• Format: Conference or Workshop Item
• Language: English; English
• Published: 2015
• Subjects: RM300 Drugs and their action; RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/44991/1/BLISS_ICAACv4.pdf; http://irep.iium.edu.my/44991/6/44991.pdf; http://irep.iium.edu.my/44991/; http://www.abstractsonline.com/Plan/ViewSession.aspx?sKey=eeeaba1b-2666-42d0-be09-8f7f806718f9

Background: This study aims to determine if continuous infusion (CI) of beta-lactam antibiotics achieves the pharmacokinetic/pharmacodynamic (PK/PD) targets for time-dependent bacterial killing and/or are associated with improved clinical outcomes compared to intermittent bolus (IB) dosing in critic...