Continuous versus intermittent beta-lactam infusion in severe sepsis: a meta-analysis of individual patient data from randomized trials

• Main Authors: Roberts, Jason A., Abdul Aziz, Mohd. Hafiz, Davis, Joshua S., Dulhunty, Joel M., Cotta, Menino O., Myburgh, John, Bellomo, Rinaldo, Lipman, Jeffrey
• Format: Article
• Language: English; English; English
• Published: American Thoracic Society 2016
• Subjects: R Medicine (General); RM Therapeutics. Pharmacology; RS Pharmacy and materia medica
• Online Access: http://irep.iium.edu.my/50325/10/roberts2016.pdf; http://irep.iium.edu.my/50325/16/50325_Continuous%20versus%20intermittent%20beta-lactam_SCOPUS.pdf; http://irep.iium.edu.my/50325/22/50325_Continuous%20versus%20intermittent%20beta-lactam%20infusion%20in%20severe%20sepsis_WoS.pdf; http://irep.iium.edu.my/50325/; http://www.atsjournals.org/doi/abs/10.1164/rccm.201601-0024OC?url_ver=Z39.88-2003&rfr_id=ori%3Arid%3Acrossref.org&rfr_dat=cr_pub%3Dpubmed&

Measurements and Main Results: We identified three randomized controlled trials in which researchers recruited a total of 632 patients with severe sepsis. The two groups were well balanced in terms of age, sex, and illness severity. The rates of hospital mortality and clinical cure for the continuou...