Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages
Runx1 transcription factor is highly expressed at a CD4/CD8-double-negative (DN) stage of thymocyte development but is down-regulated when cells proceed to the double-positive (DP) stage. In the present study, we examined whether the down-regulation of Runx1 is necessary for thymocyte differentiatio...
Saved in:
Main Authors: | Wong, W.F., Nakazato, M., Watanabe, T., Kohu, K., Ogata, T., Yoshida, N., Sotomaru, Y., Ito, M., Araki, K., Telfer, J., Fukumoto, M., Suzuki, D., Sato, T., Hozumi, K., Habu, S., Satake, M. |
---|---|
Format: | Article |
Published: |
Blackwell Publishing
2010
|
Subjects: | |
Online Access: | http://eprints.um.edu.my/13023/ http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2009.03230.x/abstract http://www.ncbi.nlm.nih.gov/pubmed/20102410 |
Tags: |
Add Tag
No Tags, Be the first to tag this record!
|
Similar Items
-
Interplay of transcription factors in T-cell differentiation and function: the role of Runx
by: Wong, W.F., et al.
Published: (2011) -
Down-regulation of Runx1 Expression by TCR Signal Involves an Autoregulatory Mechanism and Contributes to IL-2 Production
by: Wong, W.F., et al.
Published: (2011) -
The Runx3 Transcription Factor Augments Th1 and Down-Modulates Th2 Phenotypes by Interacting with and Attenuating GATA3
by: Kohu, K., et al.
Published: (2009) -
The artificial loss of Runx1 reduces the expression of quiescence-associated transcription factors in CD4(+) T lymphocytes
by: Wong, W.F., et al.
Published: (2015) -
T-cell receptor signaling induces proximal Runx1 transactivation via a calcineurin–NFAT pathway
by: Wong, W.F., et al.
Published: (2014)