Over-expression of Runx1 transcription factor impairs the development of thymocytes from the double-negative to double-positive stages

• Main Authors: Wong, W.F., Nakazato, M., Watanabe, T., Kohu, K., Ogata, T., Yoshida, N., Sotomaru, Y., Ito, M., Araki, K., Telfer, J., Fukumoto, M., Suzuki, D., Sato, T., Hozumi, K., Habu, S., Satake, M.
• Format: Article
• Published: Blackwell Publishing 2010
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/13023/; http://onlinelibrary.wiley.com/doi/10.1111/j.1365-2567.2009.03230.x/abstract; http://www.ncbi.nlm.nih.gov/pubmed/20102410

Runx1 transcription factor is highly expressed at a CD4/CD8-double-negative (DN) stage of thymocyte development but is down-regulated when cells proceed to the double-positive (DP) stage. In the present study, we examined whether the down-regulation of Runx1 is necessary for thymocyte differentiatio...