T-cell receptor signaling induces proximal Runx1 transactivation via a calcineurin–NFAT pathway

• Main Authors: Wong, W.F., Looi, C.Y., Kon, S., Movahed, E., Funaki, T., Chang, L.Y., Satake, M., Kohu, K.
• Format: Article
• Published: John Wiley & Sons 2014
• Subjects: R Medicine
• Online Access: http://eprints.um.edu.my/13042/; http://onlinelibrary.wiley.com/doi/10.1002/eji.201343496/abstract;jsessionid=F75CA764E0697FA423B4ED5641B90BA7.f03t01; http://dx.doi.org/10.1002/eji.201343496

Runx1 transcription factor is a key player in the development and function of T cells. Runx1 transcripts consist of two closely related isoforms (proximal and distal Runx1) whose expressions are regulated by different promoters. Which Runx1 isoform is expressed appears to be tightly regulated. The r...